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-Homozygous Familial Hypercholesterolemia:
Alendronate is an amino-bisphosphonate. In animal studies, alendronate locates preferentially in bone resorption sites, close to osteoclasts. Alendronate does not interfere with the recruitment of osteoclasts and their attachment but inhibits their activity. Under alendronate, normal bone is formed incorporating alendronate in its matrix where it is pharmacologically inactive. For this reason, that a scheme of administration continuous was chosen. Alendronate resorption of the bone without direct effect on the formation and thus reduces the acceleration of bone remodeling. Bone formation undergoes reduction (for bone formation and resorption are related) of lesser importance, leading to a progressive bone mass gain.
In rats during times of growth, the threshold dose that alendronate alters mineralization (causing an osteomalacia) is 6,000 times the dose which inhibited resorption. These results indicate that it is very unlikely that alendronate therapeutic dose causes an osteomalacia.
Administration of alendronate in postmenopausal women resulted in changes in biochemical markers of bone cell reworking (decrease in bone formation and resorption markers) is now for the duration of administration of the product, with a réascension or a return to the initial values after cessation of treatment.
Treatment of postmenopausal osteoporosis
Osteoporosis is defined by a bone mineral density (BMD) to the spine or to the neck of the femur to 2.5 differences types below the average value of a young normal population or by a history of fracture of brittle bone disease, independently of the DMO.
Alendronate, dose of 10 mg / day for 3 years, resulted in average increases in bone mineral density (BMD) of the lumbar vertebrae, the neck of the femur, and the trochanter of 8.8%, 5.9% and 7.8% respectively compared to placebo. These studies suggest that the lumbar bone mass increases and hips themselves are not made at the expense of the other parts of the skeleton.
I am 41 years old and I took of fosamax for several years without any side effects. This is my rheumatologist who prescribed me (and no other doctor should do). Since June I stopped the fosamax because my degration offered me an injection of a quarter of an hour and which is effect for one year. This is even better than the fosamax, less loss in intravéneux. I didn't hesitate a second a try to this treatment. result in a year.
I am 54 years old I just read your messages, I am very surprised because it uncovered that I like my mom (who broke 2 months in 1 year) osteoporosis at the same stage that it! , And it refuses to give me the FOSAMAX or FORSTEO because we cannot do as 1 treatment in 1 life! and that it is "the last card" when will you do if it worsens? those who are 40-50 years old? Rensignez you... I am very serious, I saw gyneco, degration, doctor, everyone is in agreement! I have only of calcim every evening. Please give me your "news" very quickly.
Atypical femur, spontaneous fractures or low energy - the Fosamax side effects and other bisphosphonates
Atypical fractures of the femur are described by several teams in patients taking bisphosphonates in the long term. The usefulness of treatment of more than 5 years is disputed, even when these drugs are used in their indication. And the commentators agree on the fact that must prescribe them on a case where the indication is beyond doubt and that the benefits outweigh the risks, evaluated on a case by case. The shown drug of finger is Fosamax (alendronate), but is nothing to distinguish the effects of those other bisphosphonates.

Fosamax is used to treat and prevent postmenopausal and steroid-induced osteoporosis, it stimulates formation of the bones, increases their mineral density.

Fosamax (alendronate) is in the group of medicines called bisphosphonates. It alters the cycle of bone formation and breakdown in the body. Fosamax slows bone loss while increasing bone mass, which may prevent bone fractures.